I picked that up at the bookstore yesterday, along with some Steinbeck and Kerouac. I too would rather read based on my own whim than on Oprah's latest choice, bu that's no reason to discredit East of Eden. I read it about a year ago, and it was one of the most beautiful books I have ever read. Wait til the fad dies down, then read it. I think it's worth anyone's time.
I also enjoy Harry Potter, but not because it's trendy. I like what I like be it Kesey, Robbins, or Rowling. I definately plan to wait for the paperback edition of the new book though, because who has 30 dollars to spend on a children's book, or any book for that matter?